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Axitinib and crizotinib combination therapy inhibits bone

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Axitinib and crizotinib combination therapy ... - CO

Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer . By Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Zheng Feng, Timothy Affolter, James Christensen and Gang Li.

Concise Drug Review: Pazopanib and Axitinib - The Oncologi

In a randomized, phase III clinical trial, axitinib was shown to benefit patients with mRCC after failure of one previous systemic therapy. Compared with sorafenib, axitinib led to a statistically significant and clinically meaningful longer PFS time (6.7 months versus 4.7 months; hazard ratio [HR], 0.665; one-sided p < .0001) in this study group.

JoVE | Peer Reviewed Scientific Video Journal - Methods .

Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer. Jeetendra Eswaraka , Anand Giddabasappa , Guangzhou Han , Kush Lalwani , Koleen Eisele , Zheng Feng , Timothy Affolter , James Christensen , Gang Li .

Combination strategy targeting VEGF and HGF/c-met in human .

In contrast, axitinib treatment was effective in inhibiting angiogenesis and tumor growth in both models, with its anti-tumor effect significantly increased by the combined treatment with crizotinib, independently from c-met expression. Combination treatment also induced prolonged survival and significant tumor growth inhibition in the 786-O ...

Pathogenesis of osteoblastic bone metastases from prostate .

Jeetendra Eswaraka, Anand Giddabasappa, Guangzhou Han, Kush Lalwani, Koleen Eisele, Zheng Feng, Timothy Affolter, James Christensen and Gang Li, Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer, BMC Cancer, 14, 1, (2014).

Axitinib and crizotinib combination therapy inhibits bone .

Prostate cancer (PC) is the second leading cause of new cancer cases in men worldwide. According to the Centers for Disease Control and Prevention …

A C-Met chemical inhibitor promotes fracture healing .

1. Introduction. Fracture healing and bone repair are complex processes. It is estimated that 10%–20% of fractures, especially long-bone fractures, experience delayed bone healing or even nonunion formation [], and these complications lead to severe functional and psychological conditions of the patients [].Thus, there is a high clinical demand for a new medical interventions to improve bone ...

Human Kallikrein 3/PSA Quantikine ELISA Kit DKK300: R&D .

Radium-223 inhibits osseous prostate cancer growth by dual targeting of cancer cells and bone microenvironment in mouse models Authors: MI Suominen, KM Fagerlund, JP Rissanen ... Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer.

Axitinib and crizotinib combination therapy inhibits bone .

Treatment with crizotinib alone reduced the osteolytic lesions in castrated animals. Axitinib alone reduced the osteoblastic lesions in the intact animals. Combination therapy with axitinib and crizotinib remarkably inhibited the tibial remodeling by VCaP-Luc cells which resulted in a significant reduction of both osteoblastic and osteolytic ...

RESEARCH ARTICLE Open Access Axitinib and crizotinib .

Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer Jeetendra Eswaraka1*†, Anand Giddabasappa1*†, Guangzhou Han2, Kush Lalwani1, Koleen Eisele2, Zheng Feng2, Timothy Affolter3, James Christensen2 and Gang Li2*† Abstract

Axitinib - Wikiped

Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor developed by Pfizer. It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models[2] and has shown partial responses in clinical trials with renal cell carcinoma (RCC)[3] and several other tumour types.[4] It was approved for ...

The MET/Vascular Endothelial Growth Factor Receptor (VEGFR .

For this purpose we used TAS-115, which inhibits both MET and VEGFR, and examined its effects on PC3-induced bone resorption by directly injecting PC3 cells into the proximal medulla of tibiae in nude mouse and by the co-culturing of calvarial bone with PC3 cells in vitro. We report here that oral administration of TAS-115 restored bone ...

Combination Strategy Targeting VEGF and HGF/c-met in Human .

In contrast, axitinib treatment was effective in inhibiting angiogenesis and tumor growth in both models, with its antitumor effect significantly increased by the combined treatment with crizotinib, independently from c-met expression. Combination treatment also induced prolonged survival and significant tumor growth inhibition in the 786-O ...

managing the cancer, saving the bone - nature.c

Cisplatin inhibits bone healing during distraction osteogenesis. J. Orthop. ... Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer.

Human Kallikrein 3/PSA Quantikine ELISA Kit DKK300: R .

Radium-223 inhibits osseous prostate cancer growth by dual targeting of cancer cells and bone microenvironment in ... Axitinib and crizotinib combination therapy inhibits ...

Research works produced by Gang Li | La Jolla .

13 research works produced by Gang Li with 77 citations, including: Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer

Improving the outcome of patients with castration .

Castration-resistant prostate cancer (CRPC) is now the second most common cause of male cancer-related mortality. Although docetaxel has recently been shown to extend the survival of patients with ...

Koleen Eisele | Pfizer, PA | Oncology Research Unit (OR

Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer ... crizotinib and axitinib in combination. Animals were imaged weekly by in ...

My husband has Stage IV prostate cancer with bone .

All prostate cancers are not equal and all stage 4 prostate cancers are not equal. The most common predictive value of aggressiveness is Gleason grade on biopsy. Some stage 4 patients with low grade cancers who are elderly and without pain can be ...

Publications Authored by Koleen Eisele | PubFac

Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer. Authors: Jeetendra Eswaraka Anand Giddabasappa Guangzhou Han Kush Lalwani Koleen Eisele Zheng Feng Timothy Affolter James Christensen Gang Li. BMC Cancer 2014 Oct 2;14:742. Epub 2014 Oct 2.

Prostate cancer bone metastases promote both osteolytic .

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